Host Modulation

Host response modulation in periodontics

Host response modulation (or host modulation) is a term that has been introduced to the dental profession relatively recently. In the periodontal context, and in very simple terms, it means modifying or modulating destructive or damaging aspects of the inflammatory host response that develops in the periodontal tissues as a result of the chronic challenge presented by the subgingival bacterial ...

Salmonella–Host Interactions – Modulation of the Host Innate Immune System

Salmonella enterica (S. enterica) are Gram-negative bacteria that can invade a broad range of hosts causing both acute and chronic infections. This phenotype is related to its ability to replicate and persist within non-phagocytic host epithelial cells as well as phagocytic dendritic cells and macrophages of the innate immune system. Infection with S. enterica manifests itself through a broad r...

Microbial modulation of host apoptosis and pyroptosis

1 Unit for Laboratory Animal Medicine, Department of Microbiology and Immunology, Center for Computational Medicine and Bioinformatics, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA 2 Department of Microbial Infection and Immunity, Department of Internal Medicine, Center for Microbial Interface Biology, Ohio State University, Columbus, OH, USA *Correspon...

Nutritional modulation of host responses to mycobacteria.

Nutritional status determines the generation and functioning of cellular and molecular components of the immune system which are responsible for host resistance to various infectious diseases, including tuberculosis. Studies carried out by us and others have demonstrated that malnutrition exerts detrimental effects on many aspects of host immune responses against mycobacterial infection. First,...

Host cell death modulation by Chlamydia trachomatis